Deciphering Normal Blood Gene Expression Variation—The NOWAC Postgenome Study
نویسندگان
چکیده
منابع مشابه
Deciphering Normal Blood Gene Expression Variation—The NOWAC Postgenome Study
There is growing evidence that gene expression profiling of peripheral blood cells is a valuable tool for assessing gene signatures related to exposure, drug-response, or disease. However, the true promise of this approach can not be estimated until the scientific community has robust baseline data describing variation in gene expression patterns in normal individuals. Using a large representat...
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We have developed Kvik, a system for interactive exploration of genomic data from the Norwegian Women and Cancer (NOWAC) postgenome biobank. The goal of the NOWAC study is to understand the dynamics of carcinogenesis through multi-level functional analyses of transcriptomics and epigenetics using blood and tissue samples. Kvik provides a tool for exploring gene expression data, incorporating bo...
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BACKGROUND The understanding of changes in temporal processes related to human carcinogenesis is limited. One approach for prospective functional genomic studies is to compile trajectories of differential expression of genes, based on measurements from many case-control pairs. We propose a new statistical method that does not assume any parametric shape for the gene trajectories. METHODS The ...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2010
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1000873